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There are 19 twelve-letter words containing O, P, R, U and X

AUTOEXPOSUREautoexposure n. (Photography) automatic selection of exposure settings.
AUTOEXPOSURE n. a system for automatically adjusting the aperture and/or shutter speed of a camera according to the lighting conditions.
AUXOTROPHIESauxotrophies n. Plural of auxotrophy.
AUXOTROPHY n. the state of being auxotrophic, requiring a specific growth substance beyond the minimum required for normal metabolism.
EXECUTORSHIPexecutorship n. The office or position of an executor.
EXECUTORSHIP n. the office of executor.
EXPOSTULATORexpostulator n. One who expostulates.
EXPOSTULATOR n. one who expostulates.
EXPURGATIONSexpurgations n. Plural of expurgation.
EXPURGATION n. the act of expurgating.
GROUNDPROXESGROUNDPROX n. an altitude warning system in aircraft.
HETERODUPLEXheteroduplex n. (Biochemistry) A nucleic acid composed of two chains with each derived from a different parent molecule.
heteroduplex v. To form such a compound by genetic recombination.
HETERODUPLEX n. a nucleic-acid molecule, such as DNA, composed of two chains with each derived from a different parent molecule.
ISOXSUPRINESISOXSUPRINE n. a drug which dilates blood vessels, used to inhibit contractions in premature labour and in the treatment of arteriosclerosis.
MULTIPLEXORSmultiplexors n. Plural of multiplexor.
MULTIPLEXOR n. a device enabling a computer to transmit data to many terminals by switching quickly from one user's data to another, also MULTIPLEXER.
OVEREXPOSUREoverexposure n. Excessive exposure.
overexposure n. Of a famous person, excessive publicity, publication or reporting regarding that person.
overexposure n. (Photography) Exposure of film to light during the development process for a longer time than is required…
PARADOXURINEparadoxurine adj. Of, or pertaining to, the genus Paradoxurus.
PARADOXURINE n. any of a number of palm civet species.
PNEUMOTHORAXpneumothorax n. (Medicine) Presence of air inside the pleural cavity, usually caused by injury either to the lung or the chest wall.
PNEUMOTHORAX n. accumulation of air or gas in the pleural cavity.
PORTMANTEAUXportmanteaux n. Plural of portmanteau.
PORTMANTEAU n. (French) a case opening in two parts, used for carrying clothes while traveling, also PORTMANTLE, PORTMANTUA.
POSTEXPOSUREpostexposure adj. After exposure (To radiation, pathogens, etc.).
POSTEXPOSURE adj. taking place after exposure.
PYRRHULOXIASpyrrhuloxias n. Plural of pyrrhuloxia.
PYRRHULOXIA n. a grey-and-pink crested bunting of Central and SW North America, with a short parrot-like bill.
UNDEREXPLOITunderexploit v. To exploit insufficiently.
UNDEREXPLOIT v. to make insufficient use of.
UNDEREXPOSEDunderexposed v. Simple past tense and past participle of underexpose.
UNDEREXPOSE v. to expose insufficiently.
UNDEREXPOSESunderexposes v. Third-person singular simple present indicative form of underexpose.
UNDEREXPOSE v. to expose insufficiently.
XEROMORPHOUSxeromorphous adj. Xeromorphic.
XEROMORPHOUS adj. of parts of a plant, protected against excessive loss of water by thick cuticles, coatings of hairs and similar structural features, also XEROMORPHIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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