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There are 5 five-letter words beginning with DES

DESEXdesex v. (Transitive) To remove another’s sexual characteristics or functions, often physical sterilization.
DESEX v. to remove gender attributes from.
DESHIdeshi n. (Sumo) a member of a heya ("stable"); trained by its shisho.
deshi n. Disciple, mentee, follower.
DESHI n. (Hinglish) a person of Indian, Pakistani or Bangladeshi birth who lives abroad, also DESI.
DESISdesis n. Plural of desi.
Desis n. Plural of Desi.
-desis suff. (Medicine) Binding, fusion.
DESKSdesks n. Plural of desk.
desks v. Third-person singular simple present indicative form of desk.
DESK n. a writing table.
DESSEDESSE n. (Spenser) a desk.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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