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There are 4 five-letter words beginning with EST

ESTER• ester n. (Organic chemistry) A compound most often formed by the condensation of an alcohol and an acid, with…
• Ester prop.n. A female given name from Hebrew, alternative form of Esther.
• ESTER n. a compound formed by the condensation of an alcohol and an acid, with elimination of water.
ESTOC• ESTOC n. (French) a short sword.
ESTOP• estop v. To impede or bar by estoppel.
• estop v. To stop up, to plug.
• e-stop n. An emergency stop control on machinery.
ESTRO• estro n. (Slang) Clipping of estrogen.
• estro- pref. (Biology) Estrus.
• ESTRO n. (Italian) the height of poetic inspiration.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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