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There are 2 three-letter words beginning with IO

IONion n. An atom or group of atoms bearing an electrical charge, such as the sodium and chlorine atoms in a salt solution.
ion phr. (Slang) I don’t.
Ion prop.n. (Greek mythology) Son of Creusa and Xuthus, and the ancestor of Ionian people.
IOSios n. Plural of io.
Ios prop.n. An island in the Cyclades, Greece.
iOS prop.n. (Computing, mobile telephony) A mobile operating system (OS) created and developed by Apple Inc. exclusively…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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