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There are 6 four-letter words beginning with IS

ISBAisba n. Alternative form of izba.
ISBA n. (Russian) a log hut.
ISITis␣it interj. Used other than figuratively or idiomatically: see is, it.
is␣it interj. (Canada, South Africa, Indian English, MLE, MTE) really? is that so?
is␣it part. (Singapore, Wales) Final interrogative particle forming a tag question.
ISLEisle n. A (small) island, compare with islet.
isle n. Obsolete spelling of aisle.
Isle prop.n. A city in Minnesota.
ISMSisms n. Plural of ism.
ISMs n. Plural of ISM.
ISMS n. Initialism of information security management system.
ISNAISNA prop.n. (US) Acronym of Islamic Society of North America.
ISNA v. (Scots) is not, also ISNAE.
ISOSisos n. Plural of iso.
ISOs n. Plural of ISO.
ISO n. (short for) an isolated replay, a TV and film facility.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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