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There are 4 four-letter words beginning with LOS

LOSElose v. (Transitive) To cause (something) to cease to be in one’s possession or capability due to unfortunate…
lose v. To wander from; to miss, so as not to be able to find; to go astray from.
lose v. (Transitive) To fail to win (a game, competition, trial, etc).
LOSHlosh interj. (Scotland) Expressing surprise, wonder etc.
Losh prop.n. A surname.
LOSH interj. (Scots) an interjection, Lord.
LOSSloss n. (Countable) The result of no longer possessing an object, a function, or a characteristic due to external…
loss n. (Uncountable) The destruction or ruin of an object.
loss n. (Countable) Something that has been destroyed or ruined.
LOSTlost v. Simple past tense and past participle of lose.
lost adj. Having wandered from, or unable to find, the way.
lost adj. In an unknown location; unable to be found.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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