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There are 4 five-letter words beginning with LEP

LEPER• leper n. A person who has leprosy, a person suffering from Hansen’s disease.
• leper n. (Figurative) Synonym of outcast: A person who is shunned, a pariah.
• leper v. (Now rare) To afflict with leprosy.
LEPID• lepid adj. (Obsolete) pleasant; jocose.
• LEPID adj. pleasant, jocose.
LEPRA• lepra n. (Medicine, archaic) Synonym of leprosy.
• lepra n. (Medicine, obsolete) Synonym of psoriasis.
• lepra n. (Botany, rare, obsolete) Any layer of algae, lichens, or other substance producing a leprosylike appearance…
LEPTA• lepta n. Plural of lepton (coin).
• lepta n. (Proscribed) Alternative form of lepton.
• LEPTON n. a monetary unit of Greece.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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