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There are 9 twelve-letter words beginning with OPI

OPINIONATELYopinionately adv. In a conceited manner.
OPINIONATELY adv. (obsolete) in an opinionated way.
OPINIONATINGopinionating v. Present participle of opinionate.
OPINIONATE v. to hold an opinion.
OPINIONATIVEopinionative adj. Of, pertaining to, being, or expressing opinion.
opinionative adj. (Of persons) Opinionated.
OPINIONATIVE adj. of, relating to, or consisting of opinion.
OPINIONATORSopinionators n. Plural of opinionator.
OPINIONATOR n. one who holds or gives an opinion.
OPISTHODOMOIopisthodomoi n. Plural of opisthodomos.
OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHODOMOSopisthodomos n. (Greek architecture) A porch at the rear of a temple, set against the blank back wall of the cella.
OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHOGRAPHopisthograph n. (Historical) Any early document (such as a roll of papyrus) that has writing on the back as well as the front.
opisthograph n. (Historical) Any early book that has letterpress printing on both sides of the page.
OPISTHOGRAPH n. a manuscript or slab inscribed on both back and front.
OPISTHOTONICopisthotonic adj. Relating to opisthotonus.
OPISTHOTONIC adj. of or like opisthotonos, extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region.
OPISTHOTONOSopisthotonos n. (Medicine) Sustained tetanic spasm in which the body is bent backwards and stiffened, as produced by various diseases.
OPISTHOTONOS n. extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region, etc.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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