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There are 9 twelve-letter words beginning with OPI

OPINIONATELY• opinionately adv. In a conceited manner.
• OPINIONATELY adv. (obsolete) in an opinionated way.
OPINIONATING• opinionating v. Present participle of opinionate.
• OPINIONATE v. to hold an opinion.
OPINIONATIVE• opinionative adj. Of, pertaining to, being, or expressing opinion.
• opinionative adj. (Of persons) Opinionated.
• OPINIONATIVE adj. of, relating to, or consisting of opinion.
OPINIONATORS• opinionators n. Plural of opinionator.
• OPINIONATOR n. one who holds or gives an opinion.
OPISTHODOMOI• opisthodomoi n. Plural of opisthodomos.
• OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHODOMOS• opisthodomos n. (Greek architecture) A porch at the rear of a temple, set against the blank back wall of the cella.
• OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHOGRAPH• opisthograph n. (Historical) Any early document (such as a roll of papyrus) that has writing on the back as well as the front.
• opisthograph n. (Historical) Any early book that has letterpress printing on both sides of the page.
• OPISTHOGRAPH n. a manuscript or slab inscribed on both back and front.
OPISTHOTONIC• opisthotonic adj. Relating to opisthotonus.
• OPISTHOTONIC adj. of or like opisthotonos, extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region.
OPISTHOTONOS• opisthotonos n. (Medicine) Sustained tetanic spasm in which the body is bent backwards and stiffened, as produced by various diseases.
• OPISTHOTONOS n. extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region, etc.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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