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There are 6 six-letter words beginning with OPE

OPENEDopened v. Simple past tense and past participle of open.
OPEN v. to cause to become open.
OPENERopener n. A person who opens something.
opener n. A device that opens something; specifically a tin-opener/can-opener, or a bottle opener.
opener n. (In combination) An establishment that opens.
OPENLYopenly adv. In an open manner, visibly, not covertly.
OPEN adv. affording unobstructed access, passage, or view.
OPEPESOPEPE n. (Yoruba) a West African tree yielding a hard yellowish wood used as a substitute for teak.
OPERASoperas n. Plural of opera.
OPERA n. a form of musical drama.
OPERONoperon n. A unit of genetic material that functions in a coordinated manner by means of an operator, a promoter…
OPERON n. a group of genes operating as a unit.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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