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There are 5 seven-letter words beginning with OPI

OPIATED• opiated v. Simple past tense and past participle of opiate.
• opiated adj. Treated with an opiate.
• opiated adj. Under the influence of an opiate.
OPIATES• opiates n. Plural of opiate.
• opiates v. Third-person singular simple present indicative form of opiate.
• OPIATE v. to treat with opium.
OPINING• opining v. Present participle of opine.
• opining n. The act of giving one’s opinion.
• OPINE v. to hold as an opinion.
OPINION• opinion n. A belief, judgment or perspective that a person has formed, either through objective or subjective reasoning…
• opinion n. The judgment or sentiment which the mind forms of persons or things; estimation.
• opinion n. (Obsolete) Favorable estimation; hence, consideration; reputation; fame; public sentiment or esteem.
OPIOIDS• opioids n. Plural of opioid.
• OPIOID n. a peptide that acts like opium.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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