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There are 2 seven-letter words beginning with OPO

OPORICE• oporice n. (Obsolete) A medicine prepared from quinces, pomegranates, etc.
• OPORICE n. (Greek) an old medicine made from summer fruits.
OPOSSUM• opossum n. Any American marsupial of the family Didelphidae. The common species of the United States is Didelphis virginiana.
• OPOSSUM n. (Native American) any of various small or medium-sized marsupial mammals, mostly arboreal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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