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There are 5 eight-letter words beginning with PSI

PSILOCINpsilocin n. 4-hydroxy-dimethyltryptamine, a hallucinogenic alkaloid found in most psychedelic mushrooms.
PSILOCIN n. a hallucinogenic drug found in a Mexican mushroom.
PSILOSESPSILOSIS n. (Greek) loss of hair.
PSILOSISpsilosis n. (Phonology) The sound change by which Greek lost the consonant sound /h/ during antiquity.
psilosis n. (Medicine) Sprue, a disease of the small intestine.
PSILOSIS n. (Greek) loss of hair.
PSILOTICpsilotic adj. Of or relating to psilosis.
PSILOTIC adj. relating to psilosis, loss of hair.
PSIONICSpsionics n. (Science fiction) Mental powers, especially those under conscious control, that affect physical matter…
PSIONICS n. psychic abilities as a motif in science fiction.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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