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 There is only one twelve-letter word beginning with SUBSTITUTIO| SUBSTITUTION | • substitution n. The act of substituting or the state of being substituted. • substitution n. A substitute or replacement. • substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another. |  
 Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America. Definitions are short excerpt from the WikWik.org. 
 See this list for:- English Wiktionary: 1 word
 - Scrabble in French: 1 word
 - Scrabble in Spanish: no word
 - Scrabble in Italian: no word
 - Scrabble in German: no word
 - Scrabble in Romanian: no word
 
 
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