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There are 18 twelve-letter words beginning with SEP

SEPARABILITYseparability n. The property of being separable.
SEPARABILITY n. the state of being separable.
SEPARATENESSseparateness n. The property of being separate.
SEPARATENESS n. the state of being separate.
SEPARATISTICseparatistic adj. Of or pertaining to separatists; schismatical.
SEPARATISTIC adj. relating to separatism, a belief in, movement for, or state of separation.
SEPARATIVELYseparatively adv. In a separative manner.
SEPARATIVE adv. causing separation.
SEPARATORIESseparatories n. Plural of separatory.
SEPARATORY n. an instrument for separating.
SEPARATRICESseparatrices n. Plural of separatrix.
SEPARATRIX n. a solidus; a separating line.
SEPIOSTAIRESsepiostaires n. Plural of sepiostaire.
SEPIOSTAIRE n. (French) cuttlebone, also SEPIOST, SEPIUM.
SEPTEMVIRATEseptemvirate n. A group of seven people, especially (politics) a council of seven men who share office or rule.
SEPTEMVIRATE n. government by, or group of, seven men.
SEPTENNIALLYseptennially adv. Once in every seven years.
SEPTENNIAL adv. lasting or continuing seven years; as, septennial parliaments.
SEPTENTRIONSseptentrions n. Plural of septentrion.
SEPTENTRION n. (archaic) the north.
SEPTICAEMIASsepticaemias n. Plural of septicaemia.
septicæmias n. Plural of septicæmia.
SEPTICAEMIA n. blood-poisoning with presence of bacteria and their toxins in blood, also SEPTICEMIA.
SEPTICIDALLYsepticidally adv. (Botany) In a septicidal manner.
SEPTICIDAL adv. with splitting of septa, as when a fruit dehisces by separation of the carpels.
SEPTILATERALseptilateral adj. Having seven sides.
SEPTILATERAL adj. having seven sides.
SEPTILLIONTHseptillionth adj. The ordinal form of the number septillion.
septillionth n. The person or thing in the septillionth position.
septillionth n. One of a septillion equal parts of a whole.
SEPTUAGENARYseptuagenary adj. (Now rare) Of or related to the number seventy, particularly.
septuagenary n. (Now rare) Synonym of septuagenarian: a seventy-year-old.
SEPTUAGENARY n. a septuagenarian.
SEPTUPLICATEseptuplicate adj. Seven times the number, volume, length, etc. (of something else); septuple.
septuplicate v. To multiply by seven; to septuple.
SEPTUPLICATE n. a group of seven things.
SEPULCHERINGsepulchering v. Present participle of sepulcher.
SEPULCHER v. to place in a sepulcher, also SEPULCHRE.
SEPULCHRALLYsepulchrally adv. In a sepulchral manner.
SEPULCHRAL adv. funereal; gloomy; dismal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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