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There are 5 five-letter words beginning with SIS

SISAL• sisal n. A Central American plant, Agave sisalana, cultivated for its sword-shaped leaves that yield fibers used for rope.
• sisal n. The fibre of the plant.
• sisal n. (Rare) A sisal mat.
SISES• sises n. Plural of sis.
• SIS n. (short for) sister, also SISS.
SISSY• sissy n. (Derogatory, colloquial) An effeminate boy or man.
• sissy n. (Derogatory, colloquial) A timid, unassertive or cowardly person.
• sissy n. (BDSM) A male crossdresser who adopts feminine behaviours.
SISTA• sista n. (AAVE) Pronunciation spelling of sister.
• SISTA n. an African-American woman.
SISTS• sists n. Plural of sist.
• SIST v. to stay, as judicial proceedings; to delay or suspend.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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