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There are 16 eight-letter words beginning with SIR

SIRENIAN• sirenian n. (Zoology) Any of a group of aquatic, herbivorous mammals, of the order Sirenia, including the manatees and dugong.
• SIRENIAN n. any of an order of aquatic mammals including the manatee and dugong.
SIRENISE• sirenise v. Alternative form of sirenize.
• SIRENISE v. to bewitch, also SIRENIZE.
SIRENIZE• sirenize v. To use the enticements of a siren; to fascinate.
• SIRENIZE v. to bewitch, also SIRENISE.
SIRGANGS• sirgangs n. Plural of sirgang.
• SIRGANG n. a green Asiatic jay-like bird.
SIRIASES• SIRIASIS n. sunstroke.
SIRIASIS• siriasis n. (Medicine, obsolete) sunstroke.
• SIRIASIS n. sunstroke.
SIRLOINS• sirloins n. Plural of sirloin.
• SIRLOIN n. a loin of beef, or the upper part of the loin, also SURLOIN.
SIRNAMED• sirnamed v. Simple past tense and past participle of sirname.
• SIRNAME v. to give the family name to, also SURNAME.
SIRNAMES• sirnames n. Plural of sirname.
• SIRNAME v. to give the family name to, also SURNAME.
SIROCCOS• siroccos n. Plural of sirocco.
• SIROCCO n. (Italian) a hot, dry, dusty wind blowing from North Africa to the North Mediterranean coastline, also SCIROC, SCIROCCO, SIROC.
SIRONISE• SIRONISE v. to use a particular process to treat fabric to prevent wrinkling, also SIRONIZE.
SIRONIZE• SIRONIZE v. to use a particular process to treat fabric to prevent wrinkling, also SIRONISE.
SIRTUINS• sirtuins n. Plural of sirtuin.
• SIRTUIN n. any of a group of enzymes which regulate cell metabolism and aging.
SIRUPIER• SIRUPY adj. like sirup.
SIRUPING• siruping v. Present participle of sirup.
• SIRUP v. to make into a syrup.
SIRVENTE• sirvente n. (Music, historical) A typically satirical song sung by the troubadours of Provence.
• SIRVENTE n. (French) a (usually satirical) poem or lay recited by a medieval troubadour.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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