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There are 16 eight-letter words beginning with SIGN

SIGNABLE• signable adj. That can be signed (represented in sign language).
• signable adj. Ready to have a signature affixed to it, as with a contract.
• signable adj. Available for the posting of signs.
SIGNAGES• signages n. (Chiefly India) plural of signage.
• SIGNAGE n. a system of signs in a community.
SIGNALED• signaled v. (US, Canada) simple past tense and past participle of signal.
• SIGNAL v. to make a sign.
SIGNALER• signaler n. One who signals.
• signaler n. A device that sends a signal.
• SIGNALER n. (US) one who signals, also SIGNALLER.
SIGNALLY• signally adv. In a signal manner; conspicuously.
• SIGNAL adv. notable.
SIGNETED• signeted adj. Stamped or marked with a signet.
• SIGNET v. to mark with an official seal.
SIGNIEUR• signieur n. Alternative form of seignior.
• SIGNIEUR n. (Shakespeare) a lord, esp. of manor, also SEIGNEUR, SEIGNIOR.
SIGNINGS• signings n. Plural of signing.
• SIGNING n. the use of sign language.
SIGNIORI• SIGNOR n. (Italian) an Italian title of courtesy for a man, also SIGNIOR, SIGNORE.
SIGNIORS• signiors n. Plural of signior.
• SIGNIOR n. (Italian) an Italian title of courtesy for a man, also SIGNOR, SIGNORE.
SIGNIORY• signiory n. Alternative form of seigniory.
• SIGNIORY n. the power of a seignior, also SEIGNORY, SIGNORIA, SIGNORY.
SIGNLESS• signless adj. Without a sign or signs.
• SIGNLESS adj. without signs.
SIGNORAS• signoras n. Plural of signora.
• SIGNORA n. (Italian) an Italian title of courtesy for a married woman.
SIGNORES• SIGNORE n. (Italian) an Italian title of courtesy for a man, also SIGNOR, SIGNIOR.
SIGNORIA• signoria n. Lordship, especially in medieval Italian city states.
• SIGNORIA n. (Italian) the governing body of any of various medieval Italian republics, esp. Venice.
SIGNPOST• signpost n. A post bearing a sign that gives information on directions.
• signpost n. (Cryptic crosswords) A word or phrase within a clue that serves as an indicator, rather than being fodder.
• signpost v. (Transitive) To install signposts on.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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