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There are 14 words beginning with SISS

SISS	• siss n. (US, colloquial) A hissing noise. • siss v. (US, colloquial, intransitive) To make a hissing sound. • SISS n. (short for) sister, also SIS.
SISSY	• sissy n. (Derogatory, colloquial) An effeminate boy or man. • sissy n. (Derogatory, colloquial) A timid, unassertive or cowardly person. • sissy n. (BDSM) A male crossdresser who adopts feminine behaviours.
SISSES	• sisses n. Plural of sis. • SISS n. (short for) sister, also SIS.
SISSOO	• sissoo n. A leguminous tree (Dalbergia sissoo) of northern India. • sissoo n. The dark brown compact and durable timber obtained from this tree. • SISSOO n. (Hindi) an Indian timber tree.
SISSIER	• sissier adj. Comparative form of sissy: more sissy. • SISSY adj. effeminate, also CISSY.
SISSIES	• sissies n. Plural of sissy. • SISSY n. a weak, girlish male.
SISSOOS	• sissoos n. Plural of sissoo. • SISSOO n. (Hindi) an Indian timber tree.
SISSIEST	• sissiest adj. Superlative form of sissy: most sissy. • SISSY adj. effeminate, also CISSY.
SISSYISH	• sissyish adj. Like a sissy. • SISSYISH adj. resembling a sissy.
SISSIFIED	• sissified adj. Made like a sissy; effete. • sissified v. Simple past tense and past participle of sissify. • SISSIFIED adj. like a sissy, also CISSIFIED.
SISSINESS	• sissiness n. The property of being sissy. • SISSINESS n. the state of being sissy, also SISSYNESS.
SISSYNESS	• SISSYNESS n. the state of being sissy, also SISSINESS.
SISSINESSES	• SISSINESS n. the state of being sissy, also SISSYNESS.
SISSYNESSES	• SISSYNESS n. the state of being sissy, also SISSINESS.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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See this list for:

English Wiktionary: 41 words
Scrabble in French: 4 words
Scrabble in Spanish: no word
Scrabble in Italian: 6 words
Scrabble in German: no word
Scrabble in Romanian: no word

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