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There are 3 six-letter words beginning with UPTA

UPTAKE	• uptake n. Understanding; comprehension. • uptake n. Absorption, especially of food or nutrient by an organism. • uptake n. The act of lifting or taking up.
UPTAKS	• UPTAK n. (Scots) uptake, as in gleg in the uptak.
UPTALK	• uptalk n. (Linguistics) Speech that has a rising intonation at the end of a sentence, as if it were a question; upspeak. • uptalk v. (Linguistics, intransitive) To speak with a rising intonation at the end of a sentence, as if it were… • UPTALK v. to end a declarative sentence with a rising intonation.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 3 words
Scrabble in French: no word
Scrabble in Spanish: no word
Scrabble in Italian: no word
Scrabble in German: no word
Scrabble in Romanian: no word

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