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There are 5 four-letter words ending with IFE

FIFE• fife n. A small shrill pipe, resembling the piccolo flute, used chiefly to accompany the drum in military music.
• fife v. To play this instrument.
• fife num. Used instead of five in radio communications to avoid confusion with fire.
LIFE• life n. (Uncountable) The state of organisms preceding their death, characterized by biological processes such…
• life n. The animating principle or force that keeps an inorganic thing or concept metaphorically alive (dynamic…
• life n. Lifeforms, generally or collectively.
NIFE• nife n. (Geology) nickel–iron, especially the material that makes up the core of the Earth.
• NiFe n. (Geology) Alternative form of nife.
• NIFE n. the earth's hypothetical core of nickel and iron.
RIFE• rife adj. Widespread, common, prevalent, current (mainly of unpleasant or harmful things).
• rife adj. Abounding; present in large numbers, plentiful.
• rife adj. Full of (mostly unpleasant or harmful things).
WIFE• wife n. A married woman, especially in relation to her spouse.
• wife n. The female of a pair of mated animals.
• wife n. (Scotland) Synonym of woman.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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