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There are 6 five-letter words ending with OME

BIOME• biome n. Any major regional biological community such as that of forest or desert.
• biome n. All the genomes of such a community.
• BIOME n. an extensive ecological community, esp. one with a dominant vegetation.
BROME• brome n. Any grass of the genus Bromus.
• brome n. (Chemistry, obsolete) bromine.
• BROME n. a kind of grass resembling oats, also BROMEGRASS.
CROME• crome n. (UK, East Anglia) A garden or agricultural implement with three or four tines bent at right angles…
• crome v. (UK, East Anglia) To use a crome.
• crome n. Plural of croma.
DROME• drome n. (Obsolete) The crab plover, Dromas ardeola, of North Africa.
• Drôme prop.n. One of the départements of Auvergne-Rhône-Alpes, France. Capital: Valence (INSEE code 26).
• Drôme prop.n. A river in France, tributary to the Rhône.
EXOME• exome n. (Genetics) The complete exon content of an organism or individual; the subset of the genome that excludes introns.
• EXOME n. a part of the genome consisting of exons.
GNOME• gnome n. A brief reflection or maxim; a pithy saying.
• gnome n. (Magic, alchemy, Rosicrucianism) An elemental (spirit or corporeal creature associated with a classical…
• gnome n. (Mythology, fantasy) One of a race of imaginary human-like beings, usually depicted as short and typically…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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