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There are 5 twelve-letter words containing ESIO

AESTHESIOGEN	• AESTHESIOGEN n. something producing sensation, esp. a stimulus or suggestion producing a sensory effect on a subject under hypnosis, also ESTHESIOGEN.
COHESIONLESS	• cohesionless adj. (Geology, soil science) Lacking cohesion among particles, such as in the case of sand. • COHESIONLESS adj. without cohesion.
ECCLESIOLOGY	• ecclesiology n. The branch of theology concerned with the doctrines, role etc. of a church. • ecclesiology n. The science of building and decorating churches. • ECCLESIOLOGY n. the study of church ornamentation and architecture.
ESTHESIOGENS	• ESTHESIOGEN n. something producing sensation, esp. a stimulus or suggestion producing a sensory effect on a subject under hypnosis, also AESTHESIOGEN.
SYNGENESIOUS	• syngenesious adj. (Botany, archaic or very rare) synantherous. • SYNGENESIOUS adj. having the anthers united in a tube around the style, as in Compositae.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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English Wiktionary: 55 words
Scrabble in French: 19 words
Scrabble in Spanish: 105 words
Scrabble in Italian: 21 words
Scrabble in German: no word
Scrabble in Romanian: 62 words

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