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There are 12 twelve-letter words containing ESPI

CAESPITOSELY• CAESPITOSE adv. growing in clusters or tufts.
DESPISEDNESS• despisedness n. The state or quality of being despised.
• DESPISEDNESS n. (Milton) the state of being despised.
DESPISEMENTS• despisements n. Plural of despisement.
• DESPISEMENT n. the act of despising.
DESPITEFULLY• despitefully adv. (Archaic) In a despiteful manner; spitefully.
• DESPITEFUL adv. (archaic) full of despite, malicious.
DESPITEOUSLY• despiteously adv. In a despiteous manner.
• DESPITEOUS adv. (obsolete) feeling or showing despite.
ESPIEGLERIES• espiegleries n. Plural of espieglerie.
• ESPIEGLERIE n. (French) the quality of being espiegle, roguish.
IRRESPIRABLE• irrespirable adj. Unbreathable.
• IRRESPIRABLE adj. unfit for respiration.
MARLINESPIKE• marlinespike n. Alternative spelling of marlinspike.
• marline␣spike n. Alternative spelling of marlinspike.
• MARLINESPIKE n. a tool used to separate rope strands while splicing, also MARLINGSPIKE, MARLINSPIKE.
RESPIRATIONS• respirations n. Plural of respiration.
• RESPIRATION n. breathing; the taking in of oxygen and giving out of carbon dioxide.
RESPIROMETER• respirometer n. A device used to measure the rate of respiration of living organisms, such as plants or fish.
• respirometer n. An apparatus for supplying air to a diver under water.
• RESPIROMETER n. an instrument for measuring and studying respiration.
RESPIROMETRY• respirometry n. A form of calorimetry that is used to measure the metabolic rate.
• RESPIROMETRY n. measurement by respirometer.
SYNTHESPIANS• synthespians n. Plural of synthespian.
• SYNTHESPIAN n. a computer-generated image of a film actor used in place of the actor when filming stunts.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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