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There are 12 seven-letter words containing ESPI

BESPICE• bespice v. (Transitive) To season with spice, or with some spicy drug.
• BESPICE v. (Shakespeare) to season with spice.
BESPITS• bespits v. Third-person singular simple present indicative form of bespit.
• BESPIT v. to spit upon.
DESPISE• despise v. To regard with contempt or scorn.
• despise v. To disregard or ignore.
• DESPISE v. to look down upon with contempt.
DESPITE• despite prep. In spite of, notwithstanding.
• despite n. (Obsolete) Disdain, contemptuous feelings, hatred.
• despite n. (Archaic) Action or behaviour displaying such feelings; an outrage, insult.
ESPIALS• espials n. Plural of espial.
• ESPIAL n. a scout or spy.
ESPIERS• espiers n. Plural of espier.
• ESPIER n. someone who espies.
HESPING• HESP v. (Scots) to fasten with a clasp, also HASP.
MESPILS• MESPIL n. a North American tree that produces small white flowers in spring.
RESPIRE• respire v. (Intransitive) To breathe in and out successively.
• respire v. (Cytology, intransitive) To take up oxygen and produce carbon dioxide through oxidation.
• respire v. (Transitive) To (inhale and) exhale; to breathe.
RESPITE• respite n. A brief interval of rest or relief.
• respite n. (Law) A reprieve, especially from a sentence of death.
• respite n. (Law) The delay of appearance at court granted to a jury beyond the proper term.
VESPIDS• vespids n. Plural of vespid.
• VESPID n. (Latin) a social wasp.
VESPINE• vespine adj. Of, pertaining to, or characteristic of wasps.
• VESPINE adj. of wasps; wasplike, also VESPOID.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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