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There are 2 five-letter words containing ISU

NISUS• nisus n. A mental or physical effort to attain a specific goal; a striving.
• nisus n. The periodic procreative desire manifested in the spring by birds, etc.
• nisus n. The contraction of the diaphragm and abdominal muscles to evacuate faeces or urine.
RISUS• RISUS n. (Latin) a laugh; a grin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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