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There is only one eight-letter word containing IRULE

VIRULENT• virulent adj. Of animals, plants, or substances: extremely venomous or poisonous.
• virulent adj. (Figurative) Extremely hostile or malicious; intensely acrimonious.
• virulent adj. (Medicine) Of a disease or disease-causing agent: malignant, able to cause damage to the host.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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