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There are 5 eight-letter words containing NISC

LEMNISCI• lemnisci n. Plural of lemniscus.
• LEMNISCUS n. (Latin) a band of nerve fibres.
MENISCAL• meniscal adj. Pertaining to, or having the form of, a meniscus.
• MENISCAL adj. in the shape of a meniscus.
MENISCUS• meniscus n. A crescent moon, or an object shaped like it.
• meniscus n. (Optics) A lens which is convex on one side and concave on the other, being crescent-shaped in cross-section.
• meniscus n. The curved surface of liquids in tubes, whether concave or convex, caused by the surface tension of the liquid.
ONISCOID• oniscoid n. (Zoology) A member of the Oniscoidea; a woodlouse.
• ONISCOID adj. like a woodlouse.
URANISCI• uranisci n. Plural of uraniscus.
• URANISCUS n. (Greek) the roof of the mouth.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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