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There are 3 twelve-letter words containing OTRE

ISOTRETINOIN• isotretinoin n. (Pharmacology) A cis isomer of retinoic acid that is a synthetic derivative of vitamin A, inhibits sebaceous…
• ISOTRETINOIN n. a drug derived from Vitamin A, used in the treatment of severe acne.
METHOTREXATE• methotrexate n. (Pharmacology) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
• METHOTREXATE n. a drug used in the treatment of cancer.
PROTREPTICAL• protreptical adj. (Obsolete) Adapted to persuade; hortatory; persuasive.
• PROTREPTICAL adj. exhorting or encouraging, also PROTREPTIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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