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There are 4 five-letter words containing PSI

APSIS• apsis n. (Architecture) A recess or projection, with a dome or vault, at the east end of a church; an apse.
• apsis n. (Astronomy) Either of the points in the elliptical orbit of a planet or comet where it is closest or…
• APSIS n. (Latin) the point at which a heavenly body is most or least distant from the centre of attraction.
OPSIN• opsin n. (Biochemistry) Any of a group of light-sensitive proteins in the retina.
• OPSIN n. a protein which forms part of the visual pigment rhodopsin.
PEPSI• pepsi n. (Slang, ethnic slur) Alternative form of Pepsi (“person from Quebec”).
• Pepsi prop.n. A brand of carbonated cola non-alcoholic drink produced by the company PepsiCo.
• Pepsi n. A serving of Pepsi.
PSION• psion n. The psi-meson, a sub-atomic particle.
• psion n. A person with psionic abilities.
• PSION n. a particle formed by collision of a positron and an electron.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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