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There are 8 six-letter words containing PIRE

ASPIRE• aspire v. (Intransitive) To have a strong desire or ambition to achieve something.
• aspire v. (Transitive, obsolete) To go as high as, to reach the top of (something).
• aspire v. (Intransitive, archaic, literary) To move upward; to be very tall.
EMPIRE• empire n. A political unit, typically having an extensive territory or comprising a number of territories or nations…
• empire n. A political unit ruled by an emperor or empress.
• empire n. The group of states or other territories that owe allegiance to an imperial power (foreign to them)…
EXPIRE• expire v. (Intransitive) To die.
• expire v. (Intransitive) To lapse and become invalid.
• expire v. (Intransitive) To come to an end; to conclude.
SPIREA• spirea n. Any of the many flowering shrubs of the genus Spiraea, that have clusters of white or pink flowers.
• spirea n. Any of the flowering plants of the genus Astilbe.
• SPIREA n. (Greek) a group of plants, including hardhack and meadowsweet, also SPIRAEA.
SPIRED• spired adj. Having a spire.
• 'spired v. Simple past tense and past participle of ’spire.
• SPIRE v. to rise in a tapering manner.
SPIREM• spirem n. Alternative form of spireme.
• SPIREM n. a filament forming part of a cell nucleus, also SPIREME.
SPIRES• spires n. Plural of spire.
• spires v. Third-person singular simple present indicative form of spire.
• Spires prop.n. A surname.
UMPIRE• umpire n. (Tennis, badminton) The official who presides over a tennis match sat on a high chair.
• umpire n. (Cricket) One of the two white-coated officials who preside over a cricket match.
• umpire n. (Baseball) One of the officials who preside over a baseball game.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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