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There are 3 four-letter words containing ROI

ROID• roid n. (Bodybuilding, slang) Anabolic steroids.
• roid n. (Sports, slang) Illegal and/or banned performance-enhancing steroids used by athletes and others.
• roid n. (Vulgar, slang) Hemorrhoids.
ROIL• roil v. (Transitive, of a fluid, especially a liquid) To render turbid by stirring up the dregs or sediment of.
• roil v. (Transitive, of a person or group of people) To annoy; to make angry; to throw into discord.
• roil v. (Intransitive) To bubble, seethe.
ROIN• roin v. (Obsolete, intransitive) To growl; to roar.
• roin n. (Obsolete) A scab; a scurf, or scurfy spot.
• ROIN v. (Spenser) to growl, roar, also ROYNE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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