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There are 6 eight-letter words containing RUNE

BRUNETTE• brunette adj. (Of hair, eyes, skin, etc.) of a dark color or tone.
• brunette adj. (Of a person) having brown or black hair and, often, dark eyes and darkish or olive skin.
• brunette n. A person, especially female, with brown or black hair and, often, dark eyes and darkish or olive skin.
PRUNELLA• prunella n. (Botany) A member of the genus Prunella of herbaceous plants, the allheals.
• prunella n. (Obsolete, medicine) Any of various diseases characterised by inflammation of the mouth or throat.
• prunella n. (Now rare, historical) A smooth worsted or silk fabric, generally black, formerly used for making shoes…
PRUNELLE• prunelle n. A kind of small and very acid French plum, especially when stoned and dried, from Prunus spinosa (blackthorn, sloe).
• PRUNELLE n. (French) a strong silk or woollen material, formerly used for academic and clerical gowns and women's shoes, also PRUNELLA.
PRUNELLO• prunello n. A species of dried plum; a prunelle.
• prunello n. Alternative form of prunella (woollen material).
• PRUNELLO n. (Italian) a fine kind of prune, esp. one made from a greengage.
RUNELIKE• runelike adj. Resembling a rune.
• RUNELIKE adj. like a rune.
UNPRUNED• unpruned adj. Not having been pruned.
• UNPRUNED adj. not pruned.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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