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There are 18 five-letter words containing SPO

INSPO• inspo n. (Slang) Clipping of inspiration.
• INSPO n. someone or something that is a source of inspiration.
SPODE• SPODE n. a fine china.
SPODS• spods n. Plural of spod.
• SPODs n. Plural of SPOD.
• SPOD n. a boring, studious person.
SPOIL• spoil v. (Transitive, archaic) To strip (someone who has been killed or defeated) of their arms or armour.
• spoil v. (Transitive, archaic) To strip or deprive (someone) of their possessions; to rob, despoil.
• spoil v. (Transitive, intransitive, archaic) To plunder, pillage (A city, country etc.).
SPOKE• spoke n. A support structure that connects the axle or the hub of a wheel to the rim.
• spoke n. (Nautical) A projecting handle of a steering wheel.
• spoke n. A rung of a ladder.
SPOOF• spoof n. (Countable) An act of deception; a hoax; a joking prank.
• spoof n. (Countable) A light parody.
• spoof n. (Countable, Britain, historical) A drinking game in which players hold up to three (or another specified…
SPOOK• spook n. (Informal) A ghost or phantom.
• spook n. A hobgoblin.
• spook n. (Informal) A scare or fright.
SPOOL• spool n. A reel; a device around which thread, wire or cable is wound, especially a cylinder or spindle.
• spool n. (Aviation) One of the rotating assemblies of a gas turbine engine, composed of one or more turbine stages…
• spool n. (Computing) A temporary storage area for electronic mail, etc.
SPOOM• spoom v. (Nautical) To sail briskly with the wind astern, with or without sails hoisted.
• spoom n. A sorbet containing fruit juice.
• SPOOM v. to scud before the wind.
SPOON• spoon n. An implement for eating or serving; a scooped utensil whose long handle is straight, in contrast to a ladle.
• spoon n. An implement for stirring food while being prepared; a wooden spoon.
• spoon n. A measure that will fit into a spoon; a spoonful.
SPOOR• spoor n. The track, trail, droppings or scent of an animal.
• spoor v. (Transitive) To track an animal by following its spoor.
• Spoor prop.n. An occupational surname from Middle English.
SPOOT• SPOOT n. the razor-shell mollusc.
SPORE• spore n. A reproductive particle, usually a single cell, released by a fungus, alga, or plant that may germinate into another.
• spore n. A thick resistant particle produced by a bacterium or protist to survive in harsh or unfavorable conditions.
• spore v. To produce spores.
SPORK• spork n. An eating utensil shaped like a spoon, the bowl of which is divided into tines like those of a fork…
• spork v. (Transitive) To move or impale (Food etc.) with a spork.
• SPORK n. a spoon-like shallow scoop with the addition of the tines of a fork.
SPORT• sport n. (Countable) Any activity that uses physical exertion or skills competitively under a set of rules that…
• sport n. (Countable) A person who exhibits either good or bad sportsmanship.
• sport n. (Countable) Somebody who behaves or reacts in an admirably good-natured manner, e.g. to being teased…
SPOSH• sposh n. (Archaic) soft wet ground; mud or slush.
• SPOSH n. (US) slush.
SPOTS• spots n. Plural of spot.
• spots v. Third-person singular simple present indicative form of spot.
• SPOT v. to mark with small round discolourations.
SPOUT• spout n. A tube or lip through which liquid or steam is poured or discharged.
• spout n. A stream of liquid.
• spout n. The mixture of air and water thrown up from the blowhole of a whale.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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