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There are 16 eight-letter words containing SOF

ISOFORMS• isoforms n. Plural of isoform.
• ISOFORM n. one of two or more proteins having a similar form.
OVERSOFT• oversoft adj. Too soft; too quiet.
• OVERSOFT adj. excessively soft.
RESOFTEN• resoften v. To soften again.
• RESOFTEN v. to soften again.
SEMISOFT• semisoft adj. (Especially of food) Partially soft; partially melted.
• semisoft n. (Rare) Any semisoft variety of cheese.
• semi-soft adj. Alternative spelling of semisoft.
SOFABEDS• sofabeds n. Plural of sofabed.
• sofa-beds n. Plural of sofa-bed.
• sofa␣beds n. Plural of sofa bed.
SOFFIONI• soffioni n. Plural of soffione.
• SOFFIONI n. (Italian) volcanic steam-holes.
SOFTBACK• softback n. A softcover or paperback book.
• SOFTBACK n. a book bound in a flexible paper cover.
SOFTBALL• softball n. A game similar to baseball but played with a larger and softer ball which can be thrown overhand or underhand.
• softball n. The ball used to play the sport.
• softball n. (By analogy) A question designed to be easy to answer.
SOFTCORE• softcore n. Pornography that does not contain depictions of explicit sexual penetration.
• softcore adj. (Slang, of music genres, subcultures, etc.) Less intense, committed or aggressive than hardcore.
• soft-core adj. Alternative form of softcore.
SOFTENED• softened adj. Made soft.
• softened adj. (Linguistics) aspirated.
• softened v. Simple past tense and past participle of soften.
SOFTENER• softener n. One who, or that which, softens.
• SOFTENER n. one that softens.
SOFTHEAD• softhead n. A fool; a silly or feeble-minded person.
• SOFTHEAD n. a foolish person.
SOFTLING• softling n. (Archaic) A soft, effeminate person; a voluptuary.
• SOFTLING n. (archaic) a soft, effeminate person.
SOFTNESS• softness n. The quality of being soft.
• SOFTNESS n. the state of being soft.
SOFTWARE• software n. (Computing) Encoded computer instructions, usually modifiable (unless stored in some form of unalterable…
• software n. (Military) The human beings involved in warfare, as opposed to hardware such as weapons and vehicles.
• SOFTWARE n. data used in computer operations.
SOFTWOOD• softwood n. (Countable, chiefly botany) The wood from any gymnosperm, without regard to how soft this wood is.
• softwood n. (Countable, in more general use) Wood of this kind, but limited to those that are commercial timbers.
• softwood n. (Countable, forestry) The tree or tree species that yields this wood.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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